ANEMIAS, IRON LOADING ANEMIAS, THALASSEMIA
Learning more about the various types of anemia, the
as well as the process of iron absorption, can help us to better understand iron overload!
Classification and diagnosis of iron overload Haematologica 1998 May The recent description of new conditions associated with iron overload and the identification of the genetic defect of hereditary hemochromatosis prompted us to review this subject and to redefine the diagnostic criteria of iron overload disorders.
Diabetic ketoacidosis and hypogonadotropic hypogonadism in association with transfusional hemochromatosis in a man with beta-thalassemia major. J Formos Med Assoc 2001 Jul;100(7):492-6
Treatment for Iron Overload
Deferiprone should be used in patients with thalassaemia and other patients with iron overload, who cannot receive effective or sufficient deferoxamine therapy. Optimal Wellness Health News Issue 166 August 13, 2000
Effects of iron overload on the immune system. Ann Clin Lab Sci 2000 Oct Department of Pathology, Marshall University and Huntington DVA Medical Center, West Virginia Increased body stores of iron in various clinical situations may tip the immunoregulatory balance unfavorably to allow increased growth rates of cancer cells and infectious organisms, and complicate the clinical management of preexisting acute and chronic diseases.
for the H63D mutation in the hereditary hemochromatosis (HFE) gene may lead into
severe iron overload in beta-thalassemia minor: observations in a thalassemic
Rev Invest Clin 2001 Mar-Apr Heterozygosity for beta-thalassemia (minor) by itself does not lead into iron overload; however, when it is inherited together with a homozygous state for either the H63D or the C282Y mutations of the hereditary hemochromatosis gene (HFE gene), iron overload may ensue.
Iron absorption in the thalassemia syndromes and its inhibition by tea.
N Engl J Med. 1979 Jan 4 Tea produced a 41 to 95 per cent inhibition of iron absorption. Since patients with thalassemia intermedia may absorb a large percentage of dietary iron, inhibitors of iron absorption, such as tea, may be useful in their management.
Quantitative Texture Analysis in Two-Dimensional Echocardiography: Application to the Diagnosis of Myocardial Hemochromatosis.Echocardiography. 1996 Jan Myocardial walls affected by hemochromatosis show ultrasound image texture alterations that may be quantified with digital image analysis techniques and appear mostly unrelated to hematologic and conventional, as well as radiofrequency-based, echocardiographic parameters. These changes in quantitatively evaluated echo reflectivity are present even before the development of clinical and echocardiographic signs of cardiac dysfunction.
Reduced Left Ventricular Contractile Reserve Identified by Low Dose Dobutamine Echocardiography as an Early Marker of Cardiac Involvement in Asymptomatic Patients with Thalassemia Major. Echocardiography 1996 Sep;13
Right ventricular diastolic function in beta-thalassemia major: echocardiographic and clinical correlates. Am Heart J. 2001 Mar Cardiac hemochromatosis remains the most frequent cause of death in beta-thalassemia major. Previous studies suggest an important right ventricular (RV) contribution to cardiac morbidity and mortality.
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