Make your own free website on Tripod.com
Click Here for Your Finances

Medscape   Home   Site Map   Marketplace   My Medscape   CME Center   Feedback   Help Desk

Search for "(hemochromatosis)" in Medscape's free Full-Text Articles or the Medscape Bookstore

Title
Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women [see comments]
Author
Roest M; van der Schouw YT; de Valk B; Marx JJ; Tempelman MJ; de Groot PG; Sixma JJ; Banga JD
Address
Julius Center for Patient Oriented Research, Utrecht University Medical School, The Netherlands.
Source
Circulation, 100(12):1268-73 1999 Sep 21
Abstract
Background-The genetic background of hereditary hemochromatosis (HH) is homozygosity for a cysteine-to-tyrosine transition at position 282 in the HFE gene. Heterozygosity for HH is associated with moderately increased iron levels and could be a risk factor for cardiovascular death. Methods and Results-We studied the relation between HH heterozygosity and cardiovascular death in a cohort study among 12 239 women 51 to 69 years of age residing in Utrecht, the Netherlands. Women were followed for 16 to 18 years (182 976 follow-up years). The allele prevalence of the HH gene in the reference group was 4.0 (95% CI 2.9 to 5.4). The mortality rate ratios for HH heterozygotes compared with wild types was 1.5 (95% CI 0.9 to 2.5) for myocardial infarction (n=242), 2.4 (95% CI 1.3 to 3. 5) for cerebrovascular disease (n=118), and 1.6 (95% CI 1.1 to 2.4) for total cardiovascular disease (n=530). The population-attributable risks of HH heterozygosity for myocardial infarction and cerebrovascular and total cardiovascular death were 3. 3%, 8.8%, and 4.0%, respectively. In addition, we found evidence for effect modification by hypertension and smoking. Conclusions-We found important evidence that inherited variation in iron metabolism is involved in cardiovascular death in postmenopausal women, especially in women already carrying classic risk factors.
Language
Eng
Unique Identifier
99423612


MESH Headings
Aged ; Alleles ; Cardiovascular Diseases *MO ; Cerebrovascular Disorders MO ; Female ; Hemochromatosis *GE ; Heterozygote ; Histocompatibility Antigens Class I *GE HISTOCOMPATIBILITY ANTIGENS CLASS 01 ; Human ; HLA Antigens *GE HLA A ANTIGENS ; Middle Age ; Myocardial Infarction MO ; Polymerase Chain Reaction ; Risk Factors ; Support, Non-U.S. Gov't


Publication Type
JOURNAL ARTICLE
ISSN
0009-7322
Country of Publication
UNITED STATES
CAS Registry Number
0 (Histocompatibility Antigens Class I); 0 (HLA Antigens); 0 (HLA-H antigen)

  Home   Site Map   Marketplace   My Medscape   CME Center   Feedback   Help Desk

Medscape Search Options
Select a database to search, enter a search term, then click “go.”    Advanced Search Forms

All material on this website is protected by copyright. Copyright © 1994-2000 by Medscape Inc. All rights reserved. This website also contains material copyrighted by 3rd parties. CME means Continuing Medical Education credit is available. Medscape requires 3.x browsers or better from Netscape or Microsoft.