Looking for IRON on the CT scan, Xray, MRI, etc.
Click on the titles to read links on these test procedures
& to see radiology reports and pictures.
Abnormal accumulation of iron in the liver, view of a slide at Michigan State University website
A middle aged man with diabetes mellitus and a liver mass. Steven Eliason, M.D., Elizabeth M. Brunt, M.D., Bruce R. Bacon, M.D., Leonard E. Grosso, M.D., Ph.D. SLUCARE PathLab Case of the Month
Cardiac hemochromatosis: beneficial effects of iron removal therapy. An echocardiographic study. Statistically significant increases in left ventricular (LV) mass, end-diastolic and end-systolic diameters of the left ventricle and in left atrial dimension were observed in patients with IH; significant changes of systolic function indexes (decrease in fractional shortening and ejection fraction and increase in distance of the E point to the septum) were seen as well. Am J Cardiol 1983 Oct 1
of the liver as a precancerous condition
Schweiz Rundsch Med Prax 1998 Oct 28 Patients suffering from cirrhosis of the liver due to HBV-, HCV- or HDV-infection and patients with genetic hemochromatosis exhibit a high risk for HCC.
of alleles associated with hemochromatosis and hereditary hyperferritinemia-cataract
Blood. 1998 Dec 1 Barton JC, Beutler E, Gelbart T CT scanning suggested that far more iron was stored in our patient's liver than could be mobilized by phlebotomy, indicating that this noninvasive technique lacks sufficient sensitivity for the measurement of normal or near-normal quantities of hepatic iron [This patient was a HIS het. with high ferritin, but normal TS . The ferritin was not decreased with phlebs.]
Correlation between the depth of inverted T waves and the serum level of ferritin in a deferoxamine-treated patient with primary hemochromatosis and hyperthyroidism. Jpn J Med. 1989 Mar-Apr There seemed to be a correlation between the depth of inverted T waves and the serum level of ferritin.
Diagnosis of hemochromatosis with magnetic resonance An Med Interna 2000 Aug; MRI can be useful in the evaluation of hemochromatosis among patients who refuse or have contraindication to liver biopsy.
Diagnosis of liver cirrhosis in children based on colour Doppler ultrasonography with histopathological correlation. Pediatr Radiol 1998 Nov Portal vein velocity, arterio-portal vein ratio and hepatic artery visualisation together were reliable in diagnosis of cirrhosis in the paediatric age group
Diagnosis of neonatal hemochromatosis with MR imaging and duplex Doppler
sonography Publication Date
and interpretation of iron in the liver
Semin Diagn Pathol 1998 Nov Because homozygosity for the C282Y mutation is diagnostic of the condition regardless of the liver iron concentration-to-age ratio, indication for liver biopsy in C282Y homozygotes is restricted to the assessment of prognostic lesions, such as fibrosis and iron-free-foci.
Evaluation of bone marrow iron by magnetic resonance imaging.
Ann Hematol 1997 Jun These observations suggest that MRI may be a useful and noninvasive method for systemic quantitative determination of bone marrow iron.
Gamna-Gandy bodies of the spleen detected with MR imaging. A case report.
Magn Reson Imaging 2001 Nov In this case, MR imaging revealed small siderotic nodules of the spleen, called Gamna-Gandy bodies. These lesions are found in patients with portal vein or splenic vein thrombosis, hemolytic anemia, leukemia, or lymphoma, patients receiving blood transfusions, acquired hemochromatosis, or paroxysmal nocturnal hemoglobinuria.
Getting iron out Pittsburgh Post-Gazette Tuesday, November 10, 1998
Hand and wrist arthropathies of hemochromatosis and calcium pyrophosphate deposition disease: distinct radiographic features Radiology 1983 May; Radiographic features of hand and wrist involvement in 26 patients with hemochromatosis and in 26 patients with idiopathic calcium pyrophosphate dihydrate (CPPD) crystal deposition disease were compared.
Hemochromatosis eMedicine Journal, December 7 2001, Volume 2, Number 12, Authored by Sandor Joffe, MD, Section Chief of Abdominal Imaging, Department of Radiology, Beth Israel Medical Center This article covers the pathophysiology of hemochromatosis as well as the techniques in using ULS, CT & MRI to identify iron deposition in the organs. Pictures & descriptions from scans of the abdomen are shown.
Gale Encyclopedia of Medicine The symptoms of hemochromatosis include fatigue, weight loss, weakness, shortness of breath, heart palpitations, chronic abdominal pain, and impaired sexual performance. The patient may also show symptoms commonly connected with heart failure, diabetes or cirrhosis of the liver. Changes in the pigment of the skin may appear, such as grayness in certain areas, or a tanned or yellow (jaundice) appearance.
Hemochromatosis of the pituitary gland: MR imaging
Radiology, Vol 168, 213-214 1988 Magnetic resonance imaging of the pituitary gland in a patient with secondary hemochromatosis is described. On T1-weighted images, the anterior lobe had almost no signal intensity, and only the high-signal posterior lobe was seen. These findings are compatible with the distribution of iron deposition and clinical symptoms in hemochromatosis.
by Keith Kaplan MD, Walter Reed Army Medical Center
Hepatic Pathology Index Images of normal & diseased livers.
MRI is superior to CT in demonstrating the fibrous capsule seen in 50% of the hepatomas and in delineating the tumor margin and venous invasion. Images of the liver by CT & MRI.
Hereditary haemochromatosis: a case of iron accumulation in the basal ganglia associated with a parkinsonian syndrome: J Neurol Neurosurg Psychiatry 1995 Sep Hereditary haemochromatosis should be considered in the differential diagnosis of parkinsonian syndromes, because complications of iron induced organ injury may be prevented by phlebotomy.
arthropathy in genetic hemochromatosis. Radiographic and histologic features
In this study, hip radiographs of 112 patients with genetic hemochromatosis and arthritis were reviewed, and histologic examination of 2 femoral heads was performed. Arthritis Rheum 1991 Mar
Diagnosis of Hepatocellular Carcinoma and Premalignant/Borderline Lesions
Sem Liver Disease 19(3):297-309, 1999 Early detection of hepatocellular carcinoma (HCC) has improved with recent noninvasive imaging modalities, such as ultrasonography (US), computer tomography (CT), and magnetic resonance imaging (MRI).
GALL BLADDER, & PANCREAS
Thomas A. Godwin, M.D.Department of Pathology 1995, Cornell University Medical College Descriptions of various diseases affecting these organs as well as pathology slides.
resonance imaging of the liver: current clinical applications.
Mayo Clin Proc 1993 Feb. Magnetic resonance imaging provides excellent anatomic depiction of the liver and important information about focal and diffuse diseases that affect this organ.
Magnetic resonance imaging of the pituitary gland in patients with secondary
hypogonadism due to transfusional hemochromatosis.
MAGMA. 1999 May The lower the signal intensity of the pituitary gland, the greater the serum ferritin level. The detection of pituitary iron overload on GRE T2*-weighted images is consistent with the hypothesis of hypogonadotrophic pituitary insufficiency due to iron-induced cellular damage.
Magnetic resonance iron-free nodules in genetic hemochromatosis.
Am J Gastroenterol. 1999 Apr The present data confirm the high prevalence of liver cancer at the time of diagnosis, mainly in cirrhotic patients greater than 45 years of age, and indicate that, when performing MRI for liver iron quantification, a complete hepatic MRI examination is preferable to a simple signal measurement in patients at risk for hepatocellular carcinoma.
Urbana Atlas of Pathology
University of Illinois College of Medicine at Urbana-Champaign Overview of slides & annotations.
Back to the "Munnsters" main Hemochromatosis page